The only vtt I have experience with is Roll20's, and it has built in "fog of war" to control map revelation. I expect that's a pretty basic vtt feature, so I don't think cutting up the map would be useful, especially as it doesn't organically divide into quarters, as more constructed dungeon might. For those printing it out, having it divided into both international and American paper standards ready to print could be useful (a lot of stuff only comes formatted for one or the other, and for what is basically text, having the printer resize to fit isn't too problematic, but for a map, you'd really want to keep original dimensions).